Coupling between nucleotide excision repair and gene expression

Nucleotide excision repair gene expression after Cisplatin treatment in melanoma.

Two of the hallmark features of melanoma are its development as a result of chronic UV radiation exposure and the limited efficacy of cisplatin in the disease treatment. Both of these DNA-damaging agents result in large helix-distorting DNA damage that is recognized and repaired by nucleotide excision repair (NER). The aim of this study was to examine the expression of NER gene transcripts, p53...

Prokaryotic nucleotide excision repair.

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into th...

SnapShot: Nucleotide Excision Repair

Nucleotide Excision Repair and Cancer

Cancer ranks as one of the most frequent causes of death worldwide and in Western society it is competing with cardiovascular disease as the number one killer. This high frequency in Western countries can be attributed to lifestyle and environmental factors, only 5-10% of all cancers are directly due to heredity. Common environmental factors leading to cancer include: tobacco (25-30%), diet and...

leotide Excision Repair Gene Expression after Cisplatin

Downlo of the hallmark features of melanoma are its development as a result of chronic UV radiation exposure e limited efficacy of cisplatin in the disease treatment. Both of these DNA-damaging agents result in elix-distorting DNA damage that is recognized and repaired by nucleotide excision repair (NER). The this study was to examine the expression of NER gene transcripts, p53, and p21 in mela...